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目的探讨二磷酸盐类药物缓解前列腺癌骨转移性疼痛的效果。方法计算机检索Medline(1966年至2007年12月)、Embase(1966年至2007年1月)、Cochrane图书馆(2007年第四期)及中国生物医学数据库(1979年至2007年12月),收集所有相关随机对照试验,并采用Revman4.2进行Meta-分析。结果共纳入10个随机对照试验。Meta-分析表明,与对照组相比,二磷酸盐类药物可以减轻疼痛,减少止痛剂的使用,降低了骨骼事件的发生率,但并不能改善患者的病死率。恶心在二磷酸盐类药物组发生率较高,而其他各种副作用无统计学差异。结论二磷酸盐类药物在减轻前列腺癌骨转移患者的疼痛及骨并发症上有一定作用。除恶心外,其他的副作用没有明显增加。需要进行更多的研究来提高这些结论的证据级别。
Objective To investigate the effect of bisphosphonates on relieving bone metastatic pain of prostate cancer. Methods The computer was searched for Medline (1966 - December 2007), Embase (1966 - January 2007), Cochrane Library (2007) and China Biomedical Database (1979 - December 2007) All relevant randomized controlled trials were collected and Meta-Analyzed using Revman 4.2. Results A total of 10 randomized controlled trials were included. Meta-analysis showed that compared with the control group, diphosphate drugs can reduce pain, reduce the use of analgesics, reduce the incidence of skeletal events, but does not improve patient mortality. Nausea in the bisphosphonates group a higher incidence, while the other various side effects no significant difference. Conclusion Bisphosphonates have a role in reducing pain and bone complications in patients with prostate cancer with bone metastases. In addition to nausea, other side effects did not increase significantly. More research is needed to raise the level of evidence for these conclusions.