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目的:探讨血清氨基末端脑利钠肽(NT-pro-BNP)水平与先天性心脏病肺动脉高压的相关性。方法:将52例先天性心脏病患儿分成先心病组(A组)24例,先心病并轻度肺动脉高压组(B组)15例,先心病并中重度肺动脉高压组(C组)13例,并设正常对照组(N组)20例。对所有实验对象采用电化学发光法进行血清NT-pro-BNP浓度检测,并行心脏彩超检查测量肺动脉压力。结果:血清NT-pro-BNP浓度水平在N组(91.2±16.9)pg/mL、A组(92.5±14.7)pg/mL及B组(98.1±18.3)pg/mL之间无显著差异(P>0.05),但在C组显著升高(223.6±68.1)pg/mL(P<0.01)。结论:血清NT-pro-BNP水平在先天性心脏病患儿并中重度肺高压时显著升高,可作为早期判断肺动脉高压的辅助手段。
Objective: To investigate the relationship between the serum level of NT-pro-BNP and pulmonary hypertension in congenital heart disease. Methods: Fifty-two children with congenital heart disease were divided into 24 cases in congenital heart disease group (A group), 15 cases in congenital heart disease and mild pulmonary hypertension group (B group), 13 cases in congenital heart disease group and moderate and severe pulmonary hypertension group (C group) Cases, and set the normal control group (N group) 20 cases. All subjects were examined by electrochemiluminescence for serum NT-pro-BNP concentration and pulmonary echocardiography by echocardiography. Results: There was no significant difference in serum NT-pro-BNP levels between the groups of 91.2 ± 16.9 pg / mL, 92.5 ± 14.7 pg / mL and 98.1 ± 18.3 pg / mL of group B > 0.05), but significantly increased in group C (223.6 ± 68.1) pg / mL (P <0.01). Conclusion: The level of serum NT-pro-BNP in children with congenital heart disease and moderate to severe pulmonary hypertension was significantly increased, which can be used as an early adjuvant to determine pulmonary hypertension.