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目的 探讨大肠癌患者血管内皮生长因子 (VEGF)与组织学分级和Dukes分期的关系。方法 采用逆转录—聚合酶链反应 (RT PCR)的方法 ,检测了 68例大肠癌患者肿瘤组织中VEGF表达水平。结果 肿瘤组织中VEGF表达水平在不同组织学分级之间比较 ,无显著性差异 ;DukesC、D期组显著高于DukesA、B期。结论 检测大肠癌患者VEGF的表达 ,可作为判断大肠癌分期、预测淋巴结转移和远处转移的 1个指标
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and histological grade and Dukes staging in patients with colorectal cancer. Methods Reverse transcription-polymerase chain reaction (RT PCR) was used to detect the expression of VEGF in tumor tissues of 68 patients with colorectal cancer. Results There was no significant difference in the expression of VEGF in tumor tissue between different histological grades. The Dukes C and D stages were significantly higher than Dukes A and B stages. Conclusion Detection of VEGF expression in patients with colorectal cancer can be used as an index to judge the stage of colorectal cancer, predict lymph node metastasis and distant metastasis.