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作者对曼氏血吸虫粗抗原及纯化抗原所引起的体液免疫应答是否存在家族相似性进行了研究。因为对影响血吸虫感染及临床发病的特异性基因进行鉴定与定位研究的第一步需要找出所涉及的遗传因素,而家族相似性分析为这一研究提供方法,它能定量地分析家族中同胞间同型免疫应答的相似程度。 研究对象为巴西曼氏血吸虫流行区两个村庄中的90个基本家庭,共299人,其中155名同胞分别来自42个基本家庭。他们
The authors investigated whether there was family similarity in the humoral immune response to Schistosoma mansoni crude antigen and purified antigen. Because the first step in identifying and locating specific genes that affect schistosomiasis infection and clinical morbidity needs to identify the genetic factors involved, and the family similarity analysis provides a method for this study, which quantitatively analyzes siblings in the family Similarity of the syngeneic immune response. The study population consisted of 299 basic families from 90 basic families in two villages of the endemic area of Schistosoma mansoni, 155 of whom were from 42 basic families. they