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目的探讨卵母细胞形态异常对体外受精-胚胎(IVF-ET)移植临床结局的影响。方法收集523例患者的1 147个成熟卵母细胞按照形态分为四组,其中形态正常组295个、透明带厚组236个、周隙大组301个以及颗粒粗组315个(后三组为形态异常卵母细胞)。比较四组的正常受精率、补救卵胞浆内单精子注射(R-ICSI)率、卵裂率、优胚率、着床率以及临床妊娠率。结果透明带厚组成熟卵母细胞正常受精率明显低于其他三组、R-ICSI率高于其他三组(P均<0.05)。周隙大组、颗粒粗组卵裂率低于形态正常组、透明带厚组(P均<0.05)。与形态正常组比较,形态异常三组优胚率、着床率、临床妊娠率均降低(P均<0.05)。结论卵母细胞形态异常可能影响IVF-ET临床结局。
Objective To investigate the effect of abnormal oocyte morphology on clinical outcome of IVF-ET transplantation. Methods A total of 1 147 mature oocytes of 523 patients were collected and divided into four groups according to their morphological features. Among them, 295 were normal morphology, 236 were zona pellucida, 301 were circumferential band and 315 were granular coarse group (the latter three groups Morphologically abnormal oocytes). The normal fertilization rate was compared between the four groups to recover the intracytoplasmic sperm injection (R-ICSI) rate, cleavage rate, excellent embryo rate, implantation rate and clinical pregnancy rate. Results The normal fertilization rate of mature oocytes in the zona pellucida was significantly lower than the other three groups, and the R-ICSI rate was higher than the other three groups (all P <0.05). The cleavage rate of granule group was lower than that of normal group and clear band thick group (P <0.05). Compared with the normal group, the abnormal embryo rate, implantation rate and clinical pregnancy rate of the three groups were decreased (P <0.05). Conclusion Oocyte morphology may affect the clinical outcome of IVF-ET.