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目的对药物性肝损伤进行探讨分析。方法对265例药物性肝损伤患者,进行用药时间、引起肝损伤药物种类、药物性肝损伤患者临床分型。结果3d发生药物性肝损伤4例,占1.50%,1～4周171例,占64.95%,5～12周68例,占25.66%,12周以上12例,占4.5%。起肝损伤药物种类13种;肝细胞损伤型180例,胆汁淤积型68例,混合型17例。结论药物性肝损伤大多是临床上常见和常用的药品,许多药物均可以引起,要掌握药物的性能,药物的代谢机制,毒副作用,对有肝肾疾病患者和老年患者用药须慎重,严密观察其不良反应,以减少药物性肝损伤的发生[5]。做好药物性肝损伤的预防和控制工作,重视药物安全性。
Objective To investigate and analyze drug-induced liver injury. Methods A total of 265 patients with drug-induced liver injury were divided into two groups according to the time of treatment, the types of drugs that cause liver injury, and the clinical classification of drug-induced liver injury. Results 3d drug-induced liver injury in 4 cases, accounting for 1.50%, 1 to 4 weeks in 171 cases, accounting for 64.95%, 5 to 12 weeks in 68 cases, accounting for 25.66%, 12 weeks or more in 12 cases, accounting for 4.5%. Thirteen species of hepatic injury drugs, 180 cases of hepatocellular injury, 68 cases of cholestasis and 17 cases of mixed type. Conclusion Drug-induced liver injury is mostly clinically common and commonly used drugs, many drugs can cause, to master the performance of drugs, drug metabolism, side effects, for patients with liver and kidney disease and elderly patients medication should be cautious, close observation Its adverse reactions to reduce the incidence of drug-induced liver injury [5]. Good drug prevention and control of liver injury, and pay attention to drug safety.