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目的:探讨盆腔器官脱垂(POP)患者耻骨宫颈筋膜中谷胱甘肽过氧化物酶-1(GPx1)的表达。方法:选取2010年10月至2011年6月盆底器官脱垂患者30例,其中POPⅡ级10例,POPⅢ级10例,POPⅣ级10例,并选取同期10例宫颈上皮内瘤变患者作为对照,采用免疫组化SP法检测耻骨宫颈筋膜中GPx1的表达情况。结果:GPx1在POP患者耻骨宫颈筋膜中的表达显著低于对照组(P<0.05),且其表达与POP-Q分期呈负相关(r=-0.660,P<0.05)。结论:POP的发展与组织中GPx1的含量有相关性。
Objective: To investigate the expression of glutathione peroxidase-1 (GPx1) in the pubic cervical fascia in patients with pelvic organ prolapse (POP). Methods: From October 2010 to June 2011, 30 patients with pelvic organ prolapse were selected. Among them, 10 were POP Ⅱ, 10 were POP Ⅲ and 10 were POP Ⅳ. 10 patients with cervical intraepithelial neoplasia were selected as controls The immunohistochemical SP method was used to detect the expression of GPx1 in the cervical fascia. Results: The expression of GPx1 in the pubic cervical fascia of patients with POP was significantly lower than that of the control group (P <0.05). The expression of GPx1 was negatively correlated with POP-Q staging (r = -0.660, P <0.05). Conclusion: The development of POP is related to the content of GPx1 in tissues.