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目的:研究HLA-DRB1基因多态性与新疆哈萨克族人群结核病(TB)的相关性。方法:采用病例-对照的研究方法,应用聚合酶链反应-序列特异性引物(PCR-SSP)技术对231例新疆哈萨克族肺结核患者和230例新疆哈萨克族健康对照者的13个HLA-DRB1等位基因进行分型,比较其等位基因频率(GF)并计算其比值比(OR)。结果:与新疆哈萨克族人群对照组相比,新疆哈萨克族人群结核病例组中HLA-DRB1*04显著增高(11.72%比6.75%,p<0.05,OR=1.889),HLA-DRB1*10也增高(2.86%比1.09%),但统计学上无显著性差异(Pc>0.05)。结论:HLA-DRB1*04可能是新疆哈萨克族人群结核病的易感基因。
Objective: To investigate the association between HLA-DRB1 gene polymorphism and tuberculosis (TB) in Xinjiang Kazak population. Methods: Thirteen HLA-DRB1 and other HLA-DRB1 alleles were detected in 231 Kazak tuberculosis patients in Xinjiang and 230 healthy Kazakh controls by polymerase chain reaction-sequence-specific primers (PCR-SSP) The genotypes were genotyped and the allele frequency (GF) was compared and the odds ratio (OR) was calculated. Results: HLA-DRB1 * 04 was significantly higher in Xinjiang Kazak TB patients (11.72% vs 6.75%, p <0.05, OR = 1.889) and HLA-DRB1 * 10 (2.86% vs. 1.09%), but there was no statistically significant difference (Pc> 0.05). Conclusion: HLA-DRB1 * 04 may be a susceptible gene to tuberculosis in Xinjiang Kazak population.