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目的:通过对宫腔内人工授精(IUI)临床资料的回顾性分析,探讨男性因素与IUI妊娠结局的关系。方法:回顾性分析2010年1～12月在河南省人民医院生殖医学中心进行的329个IUI治疗周期的临床资料。按照IUI结局分为妊娠组、非妊娠组,比较各组患者在男方年龄、女方年龄、不孕病史、精子参数等方面的差异。分别按照男方年龄、女方年龄、不孕年限、精子参数等指标进行分组,比较各组患者妊娠率的差异。结果:妊娠组和非妊娠组的男女双方年龄、不孕年限等指标差异均无统计学意义(P>0.05);女方年龄>35岁组临床妊娠率低于≤35岁组(P<0.05),处理后前向运动精子数<2×106条组临床妊娠率低于处理后前向运动精子数≥2×106条组(P<0.05),其余各组临床妊娠率差异无统计学意义(P>0.05)。结论:在输卵管通畅的情况下,处理后前向运动精子数≥2×106条男性不育者应尽可能采用IUI进行治疗,处理后前向运动精子数<2×106条或女方年龄偏大时可考虑IVF或ICSI。
Objective: To investigate the relationship between male factors and IUI pregnancy outcomes through retrospective analysis of intrauterine insemination (IUI) clinical data. Methods: The clinical data of 329 IUI treatment cycles in Reproductive Medicine Center of Henan Provincial People’s Hospital from January to December in 2010 were analyzed retrospectively. According to the outcome of IUI, the patients were divided into pregnancy group and non-pregnancy group. The differences in age, female’s age, history of infertility and sperm parameters were compared between groups. According to the male’s age, the female’s age, the duration of infertility, sperm parameters and other indicators were grouped to compare the differences in pregnancy rates between groups. Results: There was no significant difference in age and duration of infertility between pregnant women and non-pregnant women (P> 0.05). The clinical pregnancy rate of women aged> 35 years old was lower than that of ≤35 years old (P <0.05) (P <0.05). The clinical pregnancy rate of <2 × 106 groups was lower than that of treated groups> 2 × 106 (P <0.05) after treatment. There was no significant difference in clinical pregnancy rates between the other groups P> 0.05). Conclusion: In the case of tubal patency, the number of male infertility with forward motile sperm≥2 × 106 after treatment should be treated with IUI as much as possible, the number of motile sperm <2 × 106 or the older woman after treatment Consider IVF or ICSI.