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在证明从眼镜蛇蛇毒中提取的抗血栓素Ⅰ(ATX_1)具有抗凝、溶栓作用的基础上,以0.025mg/kg加于液体中静滴治疗AMI8例,3例在用药后3小时、2例用药后6小时心前区疼痛消失;1例在用药后1小时抬高的ST段回到基线;4例显著改善;3例CPK峰值在7小时内出现。提示此制剂可能成为有希望的溶栓药物。
On the basis of demonstrating anticoagulant and thrombolytic activity of antithrombotic agent (ATX_1) extracted from cobra venom, 8 patients were treated with intravenous infusion of 0.025mg / kg intravenous infusion of AMI, 3 patients were treated with 3 hours after administration, 2 Six hours after treatment, the pain in the anterior heart area disappeared; one case returned to baseline after 1 hour of ST elevation and 4 cases improved significantly. The peak of CPK in 3 cases appeared within 7 hours. Suggesting that this formulation may be a promising thrombolytic drug.