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载脂蛋白C-Ⅲ是一种水溶性低分子蛋白质,主要分布于血浆高密度脂蛋白、极低密度脂蛋白和乳糜微粒中。新近研究表明,载脂蛋白C-Ⅲ是脂蛋白代谢的重要调节因子,与高三酰甘油血症和心血管疾病进展相关联。载脂蛋白C-Ⅲ在代谢综合征和动脉粥样硬化中起重要作用,可能是心血管疾病进展的重要预测因子。调节载脂蛋白C-Ⅲ代谢也许是控制代谢综合征患者血脂代谢异常和治疗心血管疾病发病的一重要靶点。
Apolipoprotein C-III is a water-soluble, low-molecular-weight protein mainly distributed in plasma high density lipoprotein, very low density lipoprotein and chylomicrons. Recent studies have shown that apolipoprotein C-III is an important regulator of lipoprotein metabolism, associated with the progress of hypertriglyceridemia and cardiovascular disease. Apolipoprotein C-III plays an important role in the metabolic syndrome and atherosclerosis and may be an important predictor of cardiovascular disease progression. Regulation of apolipoprotein C-III metabolism may be an important target for the control of metabolic syndrome patients with abnormal lipid metabolism and the treatment of cardiovascular disease.