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在巴基斯坦,根除脊髓灰质炎仍是一项挑战,消灭脊髓灰质炎失败的原因是复杂的。在巴基斯坦,营养不良和微量营养素缺乏,尤其是锌缺乏,是主要的公共健康问题,可能潜在影响肠道疫苗的免疫应答,包括口服脊髓灰质炎疫苗。评估婴幼儿补锌对口服脊髓灰质炎疫苗(OPV)免疫应答的影响。在新生儿(0~14 d)中进行一项双盲、随机、安慰剂对照试验。受试者被安排接受每天10 mg锌或安慰剂的补充,共18周。2组
In Pakistan, the eradication of poliomyelitis remains a challenge, and the eradication of poliomyelitis is complicated by the failure. In Pakistan, malnutrition and micronutrient deficiencies, particularly zinc deficiency, are major public health concerns that may potentially affect the immune response to enteric vaccines, including oral polio vaccines. To evaluate the effect of zinc supplementation on oral immune response in oral poliomyelitis vaccine (OPV) in infants and young children. A double-blind, randomized, placebo-controlled trial was conducted in newborns (0-14 days). Subjects were scheduled for supplementation with 10 mg of zinc or placebo daily for 18 weeks. 2 teams