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目的:应用小鼠骨髓嗜多染红细胞(PCE)微核检测试验以探讨杏仁抗突变作用。方法:采用小鼠嗜多染红细胞和有核细胞-微核率(MCN‰)检测法,研究它潜在的抗突变性。结果:该结果能表明杏仁对两种阳性对照组分别诱发的较高微核率有明显降低作用,而且特殊环境下嗜多染红细胞比有核细胞具有较高的敏感性,差异均为非常显著(P<0.001)。结论:杏仁有抗突变,保护染色体损伤,促进DNA修复作用。此项研究抗突变性食物开发和医疗保健中具有重要实际意义。
OBJECTIVE: To investigate the anti-mutagenicity of almonds by using micronucleus test of mouse bone marrow polychromatic erythrocytes (PCE). Methods: The murine polychromatic erythrocytes and nucleated cell-micronuclear rate (MCN‰) assays were used to study its potential antimutagenicity. RESULTS: The results showed that almonds significantly reduced the higher micronucleus rate induced by the two positive control groups, and that the polychromatic erythrocytes were more sensitive than the nucleated cells in special circumstances, and the differences were very significant. (P<0.001). Conclusion: Almonds have anti-mutation, protect chromosome damage, and promote DNA repair. This research has important practical significance in the development of antimutagenic foods and medical care.