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目的 研究血管内皮生长因子 (VEGF)在膀胱癌组织中的表达及其意义 .方法 应用免疫组化两步法对 6 8例膀胱移行细胞癌和 10例正常膀胱组织的 VEGF进行检测 .结果 6 2 %的膀胱移行细胞癌组织表达 VEGF阳性 (4 2 /6 8) ,正常膀胱组织均为阴性 ,VEGF的表达与膀胱移行细胞癌的病理分级、临床分期有关 , , 级肿瘤明显高于 级(P<0 .0 1) ,浸润性肿瘤明显高于浅表性肿瘤 (P<0 .0 1) .VEGF阳性表达者预后较阴性者差 (P<0 .0 5 ) .结论 VEGF与膀胱肿瘤的生物学行为有关 .
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in bladder cancer and its significance.Methods The expression of VEGF in 68 cases of bladder transitional cell carcinoma and 10 cases of normal bladder tissue were detected by immunohistochemical method.Results 6 2 % Of bladder transitional cell carcinoma expressed VEGF positive (42/68), normal bladder tissue were negative, VEGF expression and bladder transitional cell carcinoma of the pathological grade, clinical stage, grade tumor was significantly higher than the grade (P <0.01), the infiltrative tumors were significantly higher than the superficial tumors (P <0.01) .The prognosis of patients with positive VEGF expression was worse than that of the negative ones (P0.05) .Conclusion VEGF and bladder cancer Biological behavior.