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SMS 201-995是最近研制的一种长效的生长抑制素类似物,皮下注射循环半衰期大约为100分钟,比生长抑制素本身长得多.SMS 201-995抑制生长激素的释放,已成功地用于治疗肢端肥大症.同生长抑制素一样,SMS 201-995还可抑制一些胃肠道肽,包括胰岛素、高血糖素、胃泌素、胃抑制多肽、胰多肽、血管活性肠多肽等的释放.并发现在胰岛素瘤、高血糖素瘤、血管活性肠多肽瘤的治疗上也有效益.本研究对消化性溃疡作胃部分切除术后的6例严
SMS 201-995 is a recently developed long-acting somatostatin analogue with a half-life of about 100 minutes in the subcutaneous injection cycle that is much longer than that of somatostatin itself.SMS 201-995 inhibits the release of growth hormone and has successfully For the treatment of acromegaly.As with somatostatin, SMS 201-995 can also inhibit some of the gastrointestinal peptides, including insulin, glucagon, gastrin, gastric inhibitory polypeptide, pancreatic polypeptide, vasoactive intestinal polypeptide, etc. Of the release and found that in the insulinoma, glucagonoma, vasoactive intestinal polypeptide tumor treatment is also effective in this study of peptic ulcer after partial gastrectomy in 6 cases