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目的 探讨 Ph染色体阳性急性髓系白血病 ( AML)患者细胞免疫表型及临床特征。方法 对 7例初诊为 Ph染色体阳性 AML 患者进行细胞形态学、细胞遗传学及细胞免疫表型检测 ,结合患者白细胞数、感染情况及临床治疗的疗效和生存期进行综合分析。结果 Ph染色体阳性 AML7例 ,占同期 AML 患者的 3 .5 % ,细胞免疫表型伴淋系表达率高 (占 4 2 .9% ) ,CD3 4表达均阳性。完全缓解率为 4 2 .9% ,平均生存期 11个月。结论 Ph染色体阳性 AML在细胞免疫表型、形态学及临床特征方面有其特殊性 ,疗效差 ,生存期短
Objective To investigate the cellular phenotype and clinical features of Ph chromosome positive acute myeloid leukemia (AML). Methods Seven cases of newly diagnosed Ph chromosome positive AML patients were detected by cell morphology, cytogenetics and cellular immunophenotype, combined with the number of white blood cells, infection and clinical efficacy and survival of patients with a comprehensive analysis. Results Ph chromosome positive AML 7 cases, accounting for 3.5% of patients with AML in the same period, cell immunophenotype with lymph node expression was high (42.2%), CD3 4 expression was positive. The complete remission rate was 42.9% with an average survival of 11 months. Conclusions Ph chromosome positive AML has its particularity in cellular immunophenotypic, morphological and clinical features, with poor curative effect and short survival time