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背景与目的:蛋白酪氨酸磷酸酶基因(phosphatase and tensin homolog deleted on chromosome ten,PTEN)与表皮生长因子受体(epidermal growth factor receptor,EGFR)信号途径的下游因子丝-苏氨酸激酶AKT、核因子-кB(nuclear factor-kappa B,NF-кB)以及信号转导子和转录激活子-3(signal transducer and activator of transcription-3,STAT3