p5 3基因是人类肿瘤中突变频率最高的抑癌基因 ,几乎发生于所有的恶性肿瘤 .突变基因编码的 p5 3蛋白释放入血 ,可诱发机体自身免疫应答 ,产生p5 3自身抗体 .在肿瘤病人和高危人群中检测血清 p5 3抗体可以反映早期p5 3基因突变 ,作为一种新的肿瘤生物学指标 ,p5 3抗体有望在恶性肿瘤的早期诊断、治疗、预后、监测、复发等方面发挥重要作用 The p53 gene is the most frequent tumor suppressor gene in human tumors and occurs in almost all malignant tumors. The p53 protein encoded by the mutated gene is released into the blood and can induce autoimmune responses and produce p53 autoantibodies. Detection of serum p53 antibody in high-risk populations may reflect early p53 mutations. As a new tumor biological marker, p53 antibody is expected to play an important role in the early diagnosis, treatment, prognosis, monitoring, and recurrence of malignant tumors.