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脑内组胺(histamine)作为神经递质或调质的概念已经确立.新近的神经解剖学研究揭示了下丘脑-小脑组胺能通路,这些组胺能纤维由下丘脑结节乳头核到达小脑皮层和小脑深部核团,其中以蚓部和绒球的颗粒细胞层密度最高;在小脑皮层神经元上也发现了组胺受体.但是,组胺对小脑神经元的生理学作用至今还未得到证实.由于颗粒细胞(granulecell,GrC)是小脑皮层中唯一中转苔状纤维传入信息的细胞,在小脑的功能活动中起重要作用,故我们在离体大鼠小脑脑薄片上,观察了组胺对GrC单位放电活动的影响,以探讨组胺能传入通路在小脑皮层感觉运动整合中的可能作用.
The concept of intracerebral histamine as a neurotransmitter or temper has been established, and recent neuroanatomy studies have revealed hypothalamic-cerebellar histaminergic pathways that reach the cerebellum from the hypothalamic nodule papillary nucleus Cortical and cerebellar deep nuclei, of which the vermilion and pompons have the highest density of granulosa cells and histamine receptors have been found on the cerebellar cortical neurons, but the physiological role of histamine in cerebellar neurons has not yet been obtained Confirmed that granulecell (GrC) is the only cell in the cerebellar cortex that translocates the moss fibers and plays an important role in cerebellar functional activity. Therefore, we observed in vitro rat cerebellar lamina Amine on GrC unit discharge activity in order to investigate the possible role of histamine import pathway in cerebellar cortex sensory integration.