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目的探讨免疫细胞NK细胞和B细胞水平对肝癌家族聚集性的影响。方法以广西肝癌高发区肝癌高发家族成员94人作为观察组,选取年龄±5岁,性别、民族相同,生活环境、生活水平及生活习惯相似,居住距离1 km以内的无癌原籍居民94人作为对照组。应用流式细胞仪检测两组外周血中NK细胞和B细胞。结果观察组NK细胞为(15.03±7.05)%,对照组为(16.33±7.42)%,而B细胞为(6.27±2.72)%,对照组为(5.90±2.52)%,两组NK细胞、B细胞比率差异均无统计学意义(P>0.05);观察组NK细胞/B细胞比值为2.76±1.69,显著低于对照组的3.46±2.84,差异有统计学意义(P<0.05)。结论 NK细胞/B细胞比值显著下降导致机体免疫功能失调,可能促进肝癌的发生,并导致肝癌的家族聚集性。
Objective To investigate the effect of immune cells on NK cell and B cell level on the familial aggregation of HCC. Methods A total of 94 HCC patients with high incidence of HCC in Guangxi were selected as the observation group. 94 healthy people without cancer whose living conditions, living standards and living habits were similar were selected as ± 5 years old. Control group. Flow cytometry was used to detect NK cells and B cells in peripheral blood of both groups. Results The number of NK cells in the observation group was (15.03 ± 7.05)%, that in the control group was (16.33 ± 7.42)%, that in the control group was (6.27 ± 2.72)% and that in the control group was (5.90 ± 2.52)% (P> 0.05). The ratio of NK cells to B cells in observation group was 2.76 ± 1.69, which was significantly lower than that in control group (3.46 ± 2.84, P <0.05). Conclusion The significant decrease of NK cell / B ratio leads to the imbalance of immune function, which may promote the occurrence of HCC and cause the familial aggregation of HCC.