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目的报道２１例睾丸原发性淋巴瘤，并分析其临床表现，形态特征和免疫表型。方法采用ＡＢＣ法对有石蜡标本的１７例进行免疫组化检测。结果患者年龄范围为３４～７６岁，中位年龄６２岁。临床症状和体征除有睾丸不同程度肿大外，无其它特异性的阳性发现。病变部位包括左侧睾丸１１例，右侧９例，双侧１例。组织学上均为弥漫型非何杰金淋巴瘤。１７例的免疫组化结果表明Ｂ细胞来源为５８．８％（１０／１７），Ｔ细胞来源为４１．２％（７／１７）。结论中老年人出现睾丸弥漫性肿大，首先应考虑睾丸淋巴瘤的可能。本病的确诊依赖病理学的诊断，免疫组织化学方法对于鉴别诊断非常重要
Objective To report 21 cases of primary testicular lymphoma and analyze its clinical manifestations, morphological features and immunophenotypes. Methods ABC method was used to detect the paraffin specimens of 17 cases by immunohistochemistry. Results The patients ranged in age from 34 to 76 years with a median age of 62 years. Clinical symptoms and signs in addition to varying degrees of testicular swelling, no other specific positive findings. Lesion site including the left testes in 11 cases, right in 9 cases, bilateral in 1 case. Histologically diffuse non-Hodgkin lymphoma. Immunohistochemical results of 17 cases showed that the source of B cells was 58.8% (10/17) and the source of T cells was 41.2% (7/17). Conclusion Middle-aged and elderly patients with diffuse testicular enlargement should first consider the possibility of testicular lymphoma. Diagnosis of the disease depends on the diagnosis of pathology, immunohistochemical methods for the differential diagnosis is very important