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粒细胞集落刺激因子(G-CSF)能够将骨髓干细胞动员到缺血组织参与组织修复,因而具有治疗心肌梗死的潜力.但是目前国际上对该疗法的效果尚存在争议.为了研究心肌梗死急性期内注射G-CSF对心肌纤维化及心脏功能的影响,将SD大鼠冠状动脉左前降支结扎3h后,皮下注射G-CSF(50μg/kg/d,共5d)或等量生理盐水.结果显示G-CSF注射5d后,外周血白细胞数量显著增加.3个月后,G-CSF注射显著增加了梗死范围和左心室胶原含量,损害了心脏功能.由以上可见,心肌梗死急性期内给予G-CSF治疗促进了心肌组织纤维化,并导致了心室扩张和心脏功能恶化.
G-CSF can mobilize bone marrow stem cells into ischemic tissue for tissue repair, which has the potential of treating myocardial infarction.But the effect of G-CSF is still controversial in the world.In order to study the acute stage of myocardial infarction G-CSF (50μg / kg / d for 5 days) or normal saline were injected subcutaneously 3 hours after ligation of left anterior descending coronary artery in SD rats, and the effect of G-CSF injection on myocardial fibrosis and cardiac function was observed. After 5 days G-CSF injection, the number of peripheral white blood cells increased significantly. After 3 months G-CSF injection significantly increased infarct size and left ventricular collagen content, impairing cardiac function. From the above it can be seen that acute myocardial infarction G-CSF treatment promotes myocardial fibrosis and leads to ventricular dilatation and worsening heart function.