论文部分内容阅读
鳞状上皮化生指宫颈腺上皮细胞为局灶性的鳞状上皮所取代,从鳞状上皮化生至鳞癌主要发生于移行带。移行带受年龄、激素水平、妊娠和分娩等生理过程的影响而呈动态变化。移行带细胞对人乳头瘤病毒(HPV)有特殊亲和力,对雌激素(E)的代谢与其他生殖道上皮相比明显不同。为研究在宫颈由鳞状细胞化生至鳞癌过程中E的作用,进一步阐明其分子机制。将含有0.25、0.10、0.05和O.01mg17-β雌二醇(E_2)的药片埋于K14-HPV16转基因小鼠(TGM)背部皮
Squamous metaplasia refers to cervical glandular epithelial cells replaced by focal squamous epithelium, from squamous metaplasia to squamous cell carcinoma mainly occurs in the transition zone. Migration by the age, hormone levels, pregnancy and childbirth and other physiological processes and showed a dynamic change. Migration zone cells have a special affinity for human papillomavirus (HPV), and the metabolism of estrogen (E) is significantly different from that of other genital epithelia. To investigate the role of E in squamous metaplasia to squamous cell carcinoma of the cervix, we elucidated its molecular mechanism. Pills containing 0.25, 0.10, 0.05, and 0.01 mg of 17-beta estradiol (E2) were buried in the back of K14-HPV16 transgenic mice (TGM)