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10例症状未恢复而自然杀伤(NK)细胞活性低下的Coxsackie B病毒(CBV)性心肌炎患者,经肌肉注射黄芪3～4月后,NK细胞活性明显高于治疗前;同期6例采用一般治疗的患者治疗后NK细胞活性无明显改变。所有患者经黄芪治疗后一般情况好转,症状改善。另16例有症状的心肌炎患者,静脉滴注黄芪后2天,α、γ扰素明显高于治疗前及治疗3周后;同期12例采用一般治疗者,α、γ干扰素均无明显改变。结果提示黄芪有调节病毒性心肌炎患者部分免疫失控的作用。
In 10 patients with Coxsackie B virus (CBV) myocarditis who had not recovered their natural killer (NK) cytotoxicity, the NK cell activity was significantly higher after 3 ~ 4 months of intramuscular injection of Astragalus membranaceus than that before treatment; in the same period, 6 patients were treated with general treatment Of patients treated NK cell activity no significant change. All patients improved after treatment with astragalus, the symptoms improved. Another 16 patients with symptomatic myocarditis, intravenous infusion of two days after Astragalus, α, γ-interferon was significantly higher than before treatment and after 3 weeks of treatment; the same period in 12 cases treated with general, α, γ-interferon no significant change . The results suggest that astragalus has a role in the regulation of some patients with viral myocarditis immunosuppression.