联合应用金属蛋白内肽酶抑制剂一Thiorphan与二羧基肽酶抑制剂一Captopril,显著延缓脑钠素(BNP)的血液清除和组织降解,增强其对正常血压和高血压大鼠的降压效应,提高BNP对大鼠主动脉狭窄引起的心衰和高血压的疗效。用脂质体作为药物载体联合运载酶抑制剂与BNP,可进一步增强BNP的作用。结果表明,应用酶抑制剂和(或)脂质体是增强和延长BNP生物学效应的有效措施。 Combination of Thiorphan, a metalloproteinoproteinase inhibitor, and Captopril, a dicarboxy peptidase inhibitor, significantly slows the blood clearance and tissue degradation of brain natriuretic peptide (BNP) and enhances its antihypertensive effects on normotensive and hypertensive rats , Improve BNP on aortic stenosis caused by heart failure and hypertension. The use of liposomes as drug carriers in combination with BNP and enzyme inhibitors can further enhance the role of BNP. The results show that the use of enzyme inhibitors and / or liposomes is an effective measure to enhance and prolong the biological effects of BNP.