论文部分内容阅读
视网膜色素上皮层(RPE)位于神经感觉层和 Bruch 膜之间,由单层六角形细胞组成,对视网膜起着吞噬,屏障,分泌及生理泵等多种作用。RPE 的病理改变和年龄相关性改变与视网膜的许多疾病有关。蓝光被证明可以导致 RPE 损伤,但损伤机制目前尚不完全清楚,线粒体、脂褐素和黑色素在此过程中发挥了重要作用。本文就近几年有关蓝光对 RPE 细胞内线粒体、脂褐素和黑色素的作用及其机制的研究进行综述。
The retinal pigment epithelium (RPE) is located between the neural sensory layer and the Bruch’s membrane and consists of a single layer of hexagonal cells that act as phagocytosis, barrier, secretion, and physiological pumping of the retina. Pathologic changes and age-related changes in RPE are associated with many diseases of the retina. Blu-ray has been shown to cause RPE damage, but the mechanism of injury is not fully understood at present, and mitochondria, lipofuscin and melanin play an important role in this process. In this paper, in recent years, the effects of blue light on the mitochondria, lipofuscin and melanin in RPE cells and its mechanism were reviewed.