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目的 :探讨酪氨酸对高原人体运动时一氧化氮 (NO)及其合酶 (NOS)的影响。方法 :对进驻海拔 370 0m高原半年的 4 0名健康青年随机分为酪氨酸组、乙酰唑胺组、依那普利组及对照组 ,每组 10人。在安静时、服药前、服药第 10天、第 15天及停药第 10天、第 2 0天分别采用功率自行车进行渐增负荷运动至力竭 ,测定其血清中NO、NOS含量。结果 :① 4组青年力竭运动后较安静时NO、NOS均增高 (P <0 .0 1或P <0 .0 5 ) ;②服用酪氨酸、乙酰唑胺、依那普利加硝苯地平 10天NO、NOS均增高 (P <0 .0 1或P >0 .0 5 ) ;酪氨酸组停药 2 0天药效消失 ,乙酰唑胺组、硝苯地平组停药 10天药效消失。结论 :酪氨酸、乙酰唑胺、依那普利均能增强高原运动时NOS活性 ,使NO合成增加 ,改善高原运动通气 /血流比 ,增强氧合功能 ,其中酪氨酸效果更明显。
AIM: To investigate the effect of tyrosine on nitric oxide (NO) and its synthase (NOS) during high altitude exercise. Methods: Forty healthy youths who entered the altitude of 370 0 m plateau for six months were randomly divided into tyrosine group, acetazolamide group, enalapril group and control group, with 10 in each group. In the quiet, medication, medication on the 10th day, the first 15 days and the withdrawal of the first 10 days, 20 days, respectively, the use of power cycling load exercise to exhaustion, determination of serum NO, NOS content. Results: (1) The levels of NO and NOS in young group were significantly increased after exhaustive exercise (P <0.01 or P <0.05). ② The administration of tyrosine, acetazolamide, enalapril plus nifenzene The levels of NO and NOS increased 10 days after the treatment (P <0.01 or P> 0.05). The pharmacodynamic effects disappeared in the tyrosine group for 20 days, and were discontinued in the acetazolamide and nifedipine groups for 10 days Efficacy disappeared. CONCLUSION: Tyrosine, acetazolamide and enalapril can both increase NOS activity during plateau movement, increase NO synthesis, improve plateau ventilation / blood flow ratio and enhance oxygenation function. The tyrosine effect is more obvious.