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小鼠ig 10g/kg/d山栀(乙醇提取物)×4d,其环己巴比妥睡眠时间显著延长,肝脏呈灰绿色。与之相比,同剂量其它护肝中药,如茵陈和垂盆草等均无上述作用。以大鼠验证表明,ig 4g/kg/d山栀(乙醇提取物)或250 mg/kg/d去羟栀子甙连续4d,其肝微粒体p-450含量和对硝基笨甲醚脱甲基酶活性,分别降至对照组值的30％和35％,或67％和72％。给药组大鼠肝脏均呈灰绿色。上述结果提示,大剂量山栀或其“有效”成份去羟栀子甙,或许会诱发以p-450丢失为特征的肝脏毒性。
Mouse ig 10g / kg / d Gardenia (ethanol extract) × 4d, its sleep time significantly longer cyclohexanibital, liver grayish green. In contrast, the same dose of other liver medicine, such as capillaris and sarmentosum did not have these effects. The results of rat validation showed that the content of p-450 and p-nitro-p-methylphenidate of ig 4g / kg / d gardenia (ethanol extract) or 250 mg / kg / Methyllase activity was reduced to 30% and 35%, or 67% and 72%, respectively, of the control value. The liver of the rats in treatment group showed gray-green color. The above results suggest that large doses of gardenia or its “potent” component, desmethoxy glycosides, may induce liver toxicity characterized by loss of p-450.