目的　探讨细胞间粘附分子1(ICAM1) m RNA 在重型乙型肝炎肝内的表达水平及其意义。方法　用原位杂交技术检测11 例非肝病对照者,5 例慢性无症状HBsAg 携带者(AsC) 、15 例慢性乙型肝炎和30 例重型乙型肝炎患者肝内ICAM1 mRNA 原位表达。结果　非肝病者和AsC肝细胞无ICAM1 mRNA表达;重型乙型肝炎患者肝细胞ICAM1 mRNA表达明显增强,其表达水平显著高于慢性乙型肝炎。结论　ICAM1 在重型乙型肝炎肝坏死中起重要作用 Objective To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) m RNA in the liver of patients with severe hepatitis B and its significance. Methods In situ hybridization was used to detect the expression of ICAM1 mRNA in the liver of 11 nonhepatitic controls, 5 chronic asymptomatic HBsAg carriers (AsC), 15 chronic hepatitis B patients and 30 severe hepatitis B patients. Results There was no expression of ICAM-1 mRNA in non-liver disease patients and AsC hepatocytes. The expression of ICAM-1 mRNA in hepatocytes of severe hepatitis B patients was significantly higher than that in chronic hepatitis B patients. Conclusion ICAM 1 plays an important role in hepatic necrosis of severe hepatitis B.