用皮质类固醇治疗鼻炎已有多年历史,由于全身应用所致的副作用,促使人们寻找有效的局部用药。开始时,这种努力收效甚微,不是由于疗效不高,就是由于蒙受经粘膜吸收而引起副作用的危险。1965年Norman报道了应用磷酸地塞米松喷雾剂的疗效,但以后因发现全身反应而弃用。1968年Czarny证明戊酸倍他米松治疗常年性鼻炎不引起肾上腺抑制现象。二丙酸氯地米松(beclomethasone dipropionate,BD)是一种合成的皮质类固醇,它有强抗炎作用,并能迅速被酶降解为活性较差的代谢物,这显著减少了发生全身性反应的可能性。在应用这种喷雾剂治疗支气管哮喘时已证明它有很好的疗效。最近的文献提出BD对成人和儿童的季节性 Corticosteroids have been used for the treatment of rhinitis for many years and have led to the search for effective topical treatment due to the systemic side effects. Initially, such efforts have had little effect, either because of poor efficacy or because of the risk of side effects caused by mucosal absorption. Norman 1965 reported the use of dexamethasone phosphate spray, but later discarded because of systemic reactions. In 1968 Czarny proved that betamethasone valerate treatment of perennial rhinitis does not cause adrenal suppression. Beclomethasone dipropionate (BD) is a synthetic corticosteroid that has potent anti-inflammatory effects and is rapidly enzymatically degraded to less active metabolites, which significantly reduces the risk of systemic reactions possibility. It has proven to be very effective in the treatment of bronchial asthma using this spray. Recent literature suggests seasonal BD for adults and children