论文部分内容阅读
目的检测正常妊娠和妊娠期高血压疾病患者血清中Endoglin的水平,探究其与妊娠期高血压疾病的发病关系及意义。方法采用酶联免疫吸附双抗体夹心法(ELISA)检测44例妊娠期高血压疾病患者(妊娠期高血压疾病组,其中妊娠期高血压15例、轻度子痫前期14例、重度子痫前期15例)及16例正常晚期妊娠妇女(对照组),22例正常中期妊娠妇女血清中Endoglin水平。结果妊娠期高血压疾病组血清Endoglin浓度为(2.86±2.15)ng/ml,正常晚期妊娠组为(1.14+0.46)ng/ml,两组比较差异有统计学意义(P<0.05)。妊娠期高血压、轻度子痫前期、重度子痫前期患者血清中可溶性Endoglin水平逐渐升高[分别为(1.68±0.78)ng/ml,(2.49±1.10)ng/ml,(4.44±2.94)ng/ml],各组间差异有统计学意义(P<0.05),且有随孕周增加而逐渐增加的趋势。正常中期妊娠组血清中Endoglin浓度为(0.83±0.32)ng/ml,与正常晚期妊娠组比较差异有统计学意义。结论血清Endoglin水平升高可能与妊娠期高血压疾病的发病及病情发展有关,并有可能成为疾病的预测指标。
Objective To detect the level of Endoglin in the serum of normal pregnancy and gestational hypertensive patients and to explore its relationship with the pathogenesis of hypertensive disorder complicating pregnancy. Methods Enzyme linked immunosorbent assay (ELISA) was used to detect 44 patients with gestational hypertension (gestational hypertension group, including 15 cases of gestational hypertension, 14 cases of mild preeclampsia, severe preeclampsia 15 cases), 16 normal pregnant women (control group) and 22 normal pregnant women. Results The serum Endoglin concentration in gestational hypertension group was (2.86 ± 2.15) ng / ml and that in normal late pregnancy group was (1.14 + 0.46) ng / ml, the difference was statistically significant (P <0.05). The levels of soluble endoglin in the patients with gestational hypertension, mild preeclampsia and severe preeclampsia increased gradually [(1.68 ± 0.78) ng / ml, (2.49 ± 1.10) ng / ml, (4.44 ± 2.94) ng / ml]. The differences among the groups were statistically significant (P <0.05), and there was a tendency to increase with gestational age. The concentration of endoglin in normal pregnant women was (0.83 ± 0.32) ng / ml, which was significantly different from that of normal pregnant women. Conclusion The increase of serum Endoglin level may be related to the pathogenesis and development of hypertensive disorder complicating pregnancy and may become a predictor of disease.