P物质既存在于消化道又存在于神经系统,是最早被发现的一个双重分布的脑肠肽。已经证明,P物质对神经系统的周围部分有营养作用,但它在中枢神经系统的作用尚不清楚。最近,瑞典学者Jonsson等报道:P物质可以抵抗6-羟多巴胺对大鼠脑内去甲肾上腺素能神经元的损伤作用。他们发现,给新生鼠皮下注射6-羟多巴胺,可使大脑额叶、枕叶皮质和脊髓中的内源性去甲肾上腺素含量降低。荧光组织化学方 Substance P, which exists both in the digestive tract and in the nervous system, was the first to be found as a bilaterally distributed ghrelin. Substance P has been shown to have a trophic effect on the peripheral portion of the nervous system, but its role in the central nervous system is not clear. Recently, Swedish scholar Jonsson et al reported that substance P can resist the damage of noradrenergic neurons in 6-OHDA rats. They found that subcutaneous injection of 6-hydroxydopamine to newborn rats reduced endogenous norepinephrine levels in the frontal, occipital cortex and spinal cord of the brain. Fluorescence histochemistry