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目的探讨血清总胆汁酸(TBA)在各类型肝脏疾病中的应用价值。方法采用循环酶法和速率法测定100例本院健康职工(对照组)和182例肝病患者血清TBA及常用肝功能指标。结果对照组的TBA为(3.9±2.9)μmol/L,各类型肝脏疾病均较对照组高(P<0.01),TBA和常用肝功能检测指标在不同类型肝脏疾病中的测定值的阳性率各有所不同,特别是肝癌和肝硬化在其他酶学指标不高时TBA阳性率分别达到96.0%和89.3%。结论 TBA测定是一个敏感的肝功能检测指标,能反映肝实质损伤,与各酶学指标比较,特别适用于各类型肝脏疾病诊断、疗效观察。
Objective To investigate the value of serum total bile acid (TBA) in various types of liver diseases. Methods The serum TBA and common liver function indexes of 100 cases of healthy workers in our hospital (control group) and 182 cases of liver disease were determined by enzymatic method and rate method. Results The TBA in the control group was (3.9 ± 2.9) μmol / L, and all kinds of liver diseases were higher than those in the control group (P <0.01). The positive rates of TBA and common liver function tests in different types of liver diseases were Different, especially in liver cancer and cirrhosis of other enzymological indicators are not high TBA positive rates were 96.0% and 89.3%. Conclusion TBA is a sensitive indicator of liver function, which can reflect the liver injury. Compared with various enzymatic indexes, TBA assay is especially suitable for diagnosis and treatment of various types of liver diseases.