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目的探讨偶联因子6(CF6)在先天性心脏病巨大房间隔缺损合并不同程度肺动脉高压中的变化。方法收集2010年1月至2012年8月160例巨大房间隔缺损患儿资料,患儿4~16(9.7±2.1)个月,体质量3.5~8.3(6.9±2.1)kg。根据合并肺动脉高压情况将160例患儿分为3组:房间隔缺损未合并肺动脉高压组41例为对照组,房间隔缺损合并肺动脉高压但未达到重度肺动脉高压组76例为A组,房间隔缺损合并重度肺动脉高压组43例为B组。应用放射免疫分析法检测不同组别患儿血浆中CF6的含量,比较组间差异,并对CF6含量与肺动脉高压程度的相关性进行分析。结果对照组、A组和B组CF6含量分别为(198.5±43.7)、(167.7±89.8)、(304.4±80.7)pg/mL,其中B组CF6含量较对照组和A组升高,差异有统计学意义(P<0.01),而对照组与A组之间差异无统计学意义(P>0.05)。重度肺动脉高压患儿肺动脉收缩压/血压收缩压比与血浆中CF6的含量呈正相关(r=0.781,P<0.01)。结论巨大房间隔缺损合并重度肺动脉高压患儿血浆CF6含量升高,提示其可能是重度肺动脉高压形成的重要因素之一。
Objective To investigate the effect of coupling factor 6 (CF6) on pulmonary hypertension in patients with great atrial septal defect complicated by congenital heart disease. Methods The data of 160 cases of giant atrial septal defect from January 2010 to August 2012 were collected, ranging from 4 to 16 months (9.7 ± 2.1) months. The body weight ranged from 3.5 to 8.3 (6.9 ± 2.1) kg. According to the situation of pulmonary hypertension, 160 patients were divided into 3 groups: 41 cases with atrial septal defect without pulmonary hypertension group as control group, 76 cases with atrial septal defect complicated with pulmonary hypertension but not severe pulmonary hypertension group A, atrial septum Forty-three cases with defect combined with severe pulmonary hypertension group B. Radioimmunoassay was used to detect the plasma levels of CF6 in different groups. The differences between groups were compared. The correlation between CF6 levels and the degree of pulmonary hypertension was also analyzed. Results The levels of CF6 in control group, A group and B group were (198.5 ± 43.7), (167.7 ± 89.8) and (304.4 ± 80.7) pg / mL respectively. The CF6 content in group B was higher than that in control group and group A Statistical significance (P <0.01), while there was no significant difference between control group and A group (P> 0.05). The pulmonary systolic pressure / systolic blood pressure ratio in children with severe pulmonary hypertension was positively correlated with the level of plasma CF6 (r = 0.781, P <0.01). Conclusion The increase of plasma CF6 level in children with giant atrial septal defect and severe pulmonary hypertension suggests that it may be one of the important factors in the formation of severe pulmonary hypertension.