本文通过检测系统性红斑狼疮 (SLE )患者外周血中Th1和Th2分泌IFN γ、IL 2、IL 4细胞因子的表达情况 ,探讨Th1/Th2细胞因子水平与SLE的发病关系。采用流式细胞分析法对 4 1例SLE患者和 15例健康志愿者外周血中细胞因子(IFN γ、IL 2、IL 4 )在辅助性T细胞 (CD4 )内的表达进行检测。结果活动期SLE患者Th1细胞因子的表达率较正常人明显下降 (P <0 0 1)。SLE患者Th1细胞因子 (IFN γ、IL 2 )的表达与SLEDAI之间具有明显的负相关性 (P <0 0 5 )。活动期SLE患者Th1细胞因子的表达明显下降 ,SLE患者Th1细胞因子水平与SLEDAI之间呈负相关性 This article examines the expression of cytokines such as IFN-γ, IL-2 and IL-4 secreted by Th1 and Th2 in patients with systemic lupus erythematosus (SLE), and explores the relationship between Th1 / Th2 cytokines and the pathogenesis of SLE. Flow cytometry was used to detect the expression of cytokines (IFN-γ, IL-2 and IL-4) in peripheral blood of 41 SLE patients and 15 healthy volunteers in helper T cells (CD4). Results The expression of Th1 cytokines in active SLE patients was significantly lower than that in normal controls (P <0.01). The expression of Th1 cytokines (IFNγ, IL 2) in SLE patients was significantly negatively correlated with SLEDAI (P <0.05). The activity of Th1 cytokines in patients with active SLE decreased significantly, and the levels of Th1 cytokines in patients with SLE were negatively correlated with SLEDAI