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目的探讨肺表面活性物质(PS)联合鼻塞式持续气道正压通气(NCPAP)对新生儿肺透明膜病患儿血气指标及并发症的影响。方法选取濮阳市妇幼保健院168例新生儿肺透明膜病患儿,按照随机数字表法分组,各84例,对照组予以NCPAP治疗,观察组采用PS+NCPAP治疗,观察比较两组临床疗效、血气指标[动脉血二氧化碳分压(Pa CO2)、血氧分压(Pa O2)、Pa O2/Fi O2]及并发症发生情况。结果观察组治疗总有效率为90.48%(76/84),高于对照组70.24%(59/84),差异有统计学意义(P<0.05);治疗后观察组Pa CO2低于对照组,Pa O2及Pa O2/Fi O2高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为5.95%(5/84),对照组为4.76%(4/84),差异无统计学意义(P>0.05)。结论肺表面活性物质联合鼻塞式持续气道正压通气可改善肺透明膜病患儿血气指标,提高疗效,且安全性高。
Objective To investigate the effect of pulmonary surfactant (PS) combined with nasal continuous positive airway pressure (NCPAP) on blood gas indexes and complications in neonates with hyaline membrane disease. Methods A total of 168 neonates with hyaline membrane disease were selected from Puyang MCH hospital. The patients were divided into two groups according to a random number table (n = 84). The control group was treated with NCPAP. The observation group was treated with PS + NCPAP. The clinical efficacy, Blood gas indexes [PaCO 2, Pa O 2, Pa O 2 / Fi O 2] and the incidence of complications. Results The total effective rate of the observation group was 90.48% (76/84), which was higher than that of the control group (70.24%, 59/84) (P <0.05). After treatment, the PaCO2 in the observation group was lower than that in the control group Pa O2 and Pa O2 / Fi O2 in the control group were significantly higher than those in the control group (P <0.05). The incidence of complications was 5.95% (5/84) in the observation group and 4.76% (4/84) in the control group The difference was not statistically significant (P> 0.05). Conclusions Pulmonary surfactant combined with nasal continuous positive airway pressure can improve blood gas index in children with hyaline membrane disease and improve the curative effect with high safety.