主要来源于红色青霉菌的红色青霉毒素 B,已从各种农产品(包括谷类、豆类、花生、玉米、糠麸、葵瓜籽)以及暴发疾病的猪和牛的饲料中分离出来。用红色青霉菌人工污染玉米喂饲过的猪,常可见到肝和肾的充血和出血。在实验动物中肝脏是受影响最严重的器官。由于肝脏在外来物的生物转化中起重要作用,故作者的研究一开始就检查红色青霉毒素 B 对小白鼠肝中药物代谢酶和混合功能氧化酶系统的影响。 Red penicillin B, which is mainly derived from Penicillium funiculosum, has been isolated from the feedstuffs of various agricultural products including cereals, beans, peanuts, corn, bran, and sunflower seeds as well as swine and cattle outbreaks. Artificial pollution with red penicillin corn fed pigs, liver and kidney can often be seen congestion and bleeding. The liver is the most affected organ in experimental animals. Since the liver plays an important role in the biotransformation of foreign substances, the author’s study initially examined the effect of red penicillin B on liver drug-metabolizing enzymes and mixed-function oxidase systems in mice.