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目的 :观察静脉注射剂佩尔地平对高血压急症的疗效。方法 :选择 2 0例高血压急症住院患者使用静脉注射佩尔地平治疗 ,并记录 0 .5、1、2、4、6、12、18及 2 4h血压和心率。结果 :2 0例中除 1例因不能耐受的头痛而退出外 ,19例患者在 0 .5h内血压明显下降 :收缩压由 (2 0 8.2± 14 .7)降至 (2 0 1.8± 13.3)mmHg(1mmHg =0 .133kPa) ,t =5 .6 7,P <0 .0 1) ;舒张压由 (118.3± 6 .7)降至 (10 9.7± 5 .4 )mmHg (t =6 .2 1,P <0 .0 1) ,显效率为 95 % ,有 3例 (15 % )有心悸副作用。结论 :静脉注射佩尔地平降低血压疗效肯定 ,使用安全、简单 ,副作用轻微 ,可作为高血压急症的首选药物
Objective: To observe the effect of intravenous injection of Perdipine on acute essential hypertension. Methods: 20 hospitalized hypertensive patients were treated with intravenous injection of perdipine, and the blood pressure and heart rate were recorded at 0.5, 1, 2, 4, 6, 12, 18 and 24 hours. Results: Of the 20 patients, only one of the 20 patients withdrew due to an intolerable headache. The blood pressure of the 19 patients significantly decreased within 0.5 h: the systolic pressure decreased from (20.8 ± 14.7) to (20 ± 1.8 ± 13.3) mmHg (1mmHg = 0.133kPa), t = 5.67, P <0.01); diastolic blood pressure decreased from (118.3 ± 6.7) to (10 9.7 ± 5.4) mmHg 6 .2 1, P <0. 01), markedly effective rate was 95%, 3 patients (15%) had palpitations side effects. Conclusion: Perlipine is effective in lowering blood pressure by intravenous injection, which is safe and easy to use and has mild side effects. It can be used as the first choice of emergency for hypertensive patients