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地高辛是临床最常用、最受欢迎的一种强心剂。但由于其治疗指数狭窄,故也是毒性反应较多的药物之一,其发生率约占住院使用地高辛患者的10～30%。当然,这既与患者年老或有肾功能减退、慢性肺疾病以及甲状腺功能低下等疾病有关,更重要的是与所并用的药物发生相互作用有关。据国外统计,地高辛是10种发生相互作用最多的药物之一。利赫(Leahey)报告,因地高辛的相互作用而出现不良反应的发生率约为27%。所以,地高辛的相互作用已成为临床治疗和临床药理学中受到重视的一个问题。
Digoxin is the most commonly used clinical, most popular kind of cardiotonics. However, due to its narrow therapeutic index, it is also one of the drugs with more toxic reactions, accounting for about 10% to 30% of the patients who are hospitalized with digoxin. Of course, this is both associated with the elderly or with renal dysfunction, chronic lung disease and hypothyroidism and other diseases, but more importantly, with the combination of drugs used in the interaction. According to foreign statistics, digoxin is one of the 10 most interacting drugs. Leahey reports about 27% of adverse reactions due to digoxin interactions. Therefore, the interaction of digoxin has become one of the most important issues in clinical treatment and clinical pharmacology.