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目的 研究血小板T细胞活化抗原 1(PTA1)分子在NK细胞杀伤过程中的作用。方法 应用重导向细胞毒实验 ,探讨了PTA1分子对混合淋巴细胞反应中活化的NK细胞杀伤作用的影响。结果 在重导向细胞毒实验中 ,PTA1McAb能明显上调NK细胞及CTL的杀伤活性。结论 PTA1分子在NK细胞上具有刺激性受体的功能。
Objective To study the role of platelet-derived T cell activating antigen 1 (PTA1) in NK cell killing. Methods Using the redirecting cytotoxicity assay, the effect of PTA1 on cytotoxicity of activated NK cells in mixed lymphocyte reaction was investigated. Results In the redirect cytotoxicity assay, PTA1McAb significantly up-regulated the killing activity of NK cells and CTL. Conclusion PTA1 has the function of stimulatory receptor on NK cells.