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目的:分析含左氧氟沙星联合化疗方案在耐多药肺结核(MDR-TB)治疗中的疗效。方法:将84例MDR-TB患者随机分为治疗组(42例),对照组(42例);治疗组:采用左氧氟沙星联合异烟肼/对氨基水杨酸钠、利福喷汀、乙胺丁醇、吡嗪酰胺;对照组:采用硫酸链霉素、异烟肼/对氨基水杨酸钠、利福喷汀、乙胺丁醇、吡嗪酰胺,疗程均为12月。结果:治疗组42例观察6月痰菌阴转率69.05%(29/42),对照组42例观察6月痰菌阴转率40.48%;前者痰菌阴转率明显高于后者(P<0.01),并且病灶显著吸收,吸收率为57.14%,后者吸收率为28.57%,两组吸收率比较,治疗组优于对照组(P<0.01);治疗组药物不良反应发生率为26.19%(11/42),对照组为30.95%(13/42),经比较差异无统计学意义(P<0.05)。结论:含左氧氟沙星的联合化疗方案治疗MDR-TB,有助于痰菌阴转和病灶吸收,且药物不良反应低。
Objective: To analyze the efficacy of levofloxacin combined with chemotherapy in the treatment of multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods: Eighty-four patients with MDR-TB were randomly divided into treatment group (n = 42) and control group (n = 42). The treatment group was treated with levofloxacin plus isoniazid / sodium p-aminosalicylate, rifapentine, Butanol and pyrazinamide. The control group was treated with streptomycin sulfate, isoniazid, sodium p-aminosalicylate, rifapentine, ethambutol and pyrazinamide for 12 months. Results: In 42 cases of treatment group, sputum negative conversion rate was 69.05% (29/42) in June and 42.4% in control group, the sputum negative conversion rate was 40.48%. The former sputum negative conversion rate was significantly higher than the latter (P <0.01), and the lesions were significantly absorbed, the absorption rate was 57.14%, the latter absorption rate was 28.57%. The absorption rate of the two groups was better than that of the control group (P <0.01). The adverse drug reaction rate in the treatment group was 26.19 % (11/42) in the control group and 30.95% (13/42) in the control group, respectively. There was no significant difference between the two groups (P <0.05). CONCLUSION: Combination therapy with levofloxacin in the treatment of MDR-TB is helpful for the negative conversion of sputum and the absorption of the lesion, and the adverse drug reaction is low.