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目的探讨孕激素对先兆流产患者血清孕激素诱导阻断因子(PIBF)水平变化及妊娠结局的影响。方法选取70例先兆流产患者为实验组,20例先兆流产患者为观察组,70例同期正常孕妇为对照组。实验组给予孕激素辅以中成药(如滋肾育胎丸、保胎灵等)或中药寿胎丸加减治疗,观察组不予任何治疗。收集3组孕妇孕7、8、12周血清样本,采用ELISA法检测血清PIBF水平,并统计3组孕妇妊娠结局。结果孕7周,实验组与观察组血清PIBF水平比较差异无统计学意义(P>0.05),但实验组血清PIBF水平低于对照组(P<0.05)。孕8、12周,实验组与对照组血清PIBF水平比较差异无统计学意义(P>0.05),实验组与观察组血清PIBF水平比较差异有统计学意义(P<0.05)。对照组与实验组足月分娩率比较差异无统计学意义(P>0.05),但均显著高于观察组(P<0.05);对照组与实验组流产率比较差异无统计学意义(P>0.05),但均显著低于观察组(P<0.05)。结论孕激素可提高先兆流产患者外周血PIBF水平,改善妊娠结局,这种作用可能与PIBF表达上调有关。
Objective To investigate the effect of progesterone on serum progesterone-inducible blocking factor (PIBF) level and pregnancy outcome in patients with threatened abortion. Methods 70 cases of threatened abortion were selected as experimental group, 20 cases of threatened abortion as observation group and 70 cases of normal pregnant women as control group. Experimental group given progesterone supplemented with proprietary Chinese medicines (such as Zishen Yu fetal pills, Paul child, etc.) or Chinese medicine Shoutai Wan addition and subtraction treatment, the observation group without any treatment. Three groups of pregnant women were collected at 7, 8, and 12 weeks of gestation. Serum PIBF levels were measured by ELISA. Pregnancy outcomes were compared among the three groups. Results There was no significant difference in serum PIBF levels between the experimental group and the observation group at 7 weeks of gestation (P> 0.05). However, serum PIBF level in the experimental group was lower than that in the control group (P <0.05). There was no significant difference in serum PIBF levels between the experimental group and the control group at 8 and 12 weeks of gestation (P> 0.05). There was significant difference in serum PIBF levels between the experimental group and the observation group (P <0.05). There was no significant difference in term delivery between the control group and the experimental group (P> 0.05), but both were significantly higher than those in the observation group (P <0.05). There was no significant difference in abortion rates between the control group and the experimental group (P> 0.05), but significantly lower than the observation group (P <0.05). Conclusions Progesterone can increase peripheral blood PIBF levels and improve pregnancy outcomes in patients with threatened abortion, which may be related to the up-regulation of PIBF.