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Smith等回顾性地研究了神经管缺损(NTD)与妊娠早期母体患发热性疾病的因果关系。1962年到1976年京都大学先天异常研究中心收集了113例神经管缺损胎儿。包括人工流产、先兆自然流产和初次自然流产者。对照组为用相同方法收集到的人胚,共分三种情况:(1)人工流产的正常胎儿;(2)107例前脑缺损(Hp)胎儿;(3)121例多指畸胎。前脑缺损或多指畸胎并发NTD 者不用作对照。每一标本的有关情况
Smith et al retrospectively studied the causal relationship between neural tube defects (NTD) and febrile maternal fever in early pregnancy. From 1962 to 1976 Kyoto University Innate Abnormal Research Center collected 113 cases of neural tube defects in the fetus. Including abortion, threatened spontaneous abortion and first spontaneous abortion. The control group was collected by the same method of human embryos, divided into three situations: (1) abortion of normal fetuses; (2) 107 cases of forebrain defects (Hp) fetus; (3) 121 cases of multi-finger teratogenesis. NTDs with forebrain defects or multiple finger teratoses were not used as controls. The status of each specimen