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目的了解静脉吸毒人群HIV血清抗体阳转率和队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系。方法于2002年11月,在四川省西昌市从社区筛查HIV抗体阴性的静脉吸毒人群前瞻性研究队列333人。在队列每6个月随访时进行HIV抗体检测来估算HIV血清抗体阳转率和分析队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系。结果静脉吸毒人群队列12个月的HIV血清抗体阳转率为3.17×10-2人年(95%CI=0.98~5.37)和保持率为70.3%。在多因素Logistic回归分析中,与队列12个月保持率差异有统计学意义的变量为6个月能随访到(OR=8.74,95%CI=4.95~15.41;P<0.0001)和彝族(OR=0.50,95%CI=0.28~0.87;P<0.0151)。未见静脉吸毒人群队列本底的HIV高危行为因素与队列12个月保持率的关系差异有统计学意义。结论静脉吸毒人群HIV血清抗体阳转率彝族和6个月未随访到的吸毒人群队列12个月的保持率低。
Objective To understand the socio-demographic and high-risk behavioral characteristics of HIV seroconversion and cohort background among intravenous drug users and the relationship between 6-month follow-up and cohort 12-month retention. Methods In a prospective cohort of 333 HIV-negative intravenous drug users from community-based screening in Xichang, Sichuan Province in November 2002, HIV antibody testing at the 6-month follow-up of the cohort to estimate HIV seroconversion rates and analysis of the cohort demographic socio-demographic and high-risk behavioral characteristics and the 6-month follow-up relationship with cohort 12-month retention. Results The seroconversion rate of HIV seroclear antibody in 12-month cohort of intravenous drug users was 3.17 × 10-2 person-years (95% CI = 0.98-5.37) and the retention rate was 70.3%. In the multivariate Logistic regression analysis, the statistically significant difference between the 12-month cohort and the cohort was 6 months follow-up (OR = 8.74, 95% CI = 4.95-15.41; P <0.0001) = 0.50, 95% CI = 0.28-0.87; P <0.0151). There was no significant difference in the relationship between high-risk behaviors of HIV and cohort 12-month retention rate after intravenous drug use. Conclusions HIV-seroconversion rate in HIV-infected population was lower in 12 months in HIV-positive cohorts and in 6-month unexplored HIV-infected cohorts.