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合68、克矽平、汉甲素和合68+克矽平联合用药治疗大鼠矽肺,100天后解剖,测定肺湿重和肺胶元蛋白含量,治疗各组均低于矽肺对照组,T/C 值分布在0.4～0.6之间,其差异有显著性意义,病理改变亦较矽肺对照组轻,显示上述药物对大鼠矽肺有一定的治疗效果,能延缓矽肺病变的发展。支气管肺冲洗细胞计数,治疗各组均低于矽肺对照组,提示合68,克矽平和合68+克矽平联合用药的治疗作用可能是保护肺泡巨噬细胞。汉防己甲素的作用机理有待探索。
Combination of 68, Keqinping, ginsenoside, and Hexan 68+ Keqiuping combined treatment of silicosis in rats, dissected 100 days later, determination of lung wet weight and lung collagen protein content, the treatment group were lower than the control group of silicosis, T/ The C values ranged from 0.4 to 0.6. The difference was significant. The pathological changes were also milder than those in the control group. This showed that the above drugs had a certain therapeutic effect on silicosis in rats and could delay the development of silicosis. The bronchoalveolar lavage cell counts were lower in the treatment group than in the silicosis control group, suggesting that combination 68, Kefu Pinghe Hehe 68+ Ke QiPing combination therapy may protect alveolar macrophages. The mechanism of action of tetrandrine has yet to be explored.