【摘 要】
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Neurodegenerative diseases include several kinds of neurological disorder that are caused by the progressive death of neurons in different regions of the brain.Such diseases affect millions of people worldwide and impose a heavy health burden on modem soc
【机 构】
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Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medica
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Neurodegenerative diseases include several kinds of neurological disorder that are caused by the progressive death of neurons in different regions of the brain.Such diseases affect millions of people worldwide and impose a heavy health burden on modem societies.However, their pathogenesis remains elusive, and disease-modifying methods are not currently available to prevent, halt, or reverse them [1].A common feature of neurodegenerative diseases is that the abnormal accumulation of misfolded proteins, such as amyloid beta (Aβ), tau, α-synuclein, fused in sarcoma (FUS), and TAR DNA-binding protein 43 (TDP-43) in the brain leads to selective neuronal degeneration and dysfunction.Dysfunction in the removal of these misfolded proteins from the brain is thought to be a major cause of neurodegenerative diseases and a major therapeutic target for their cure.
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