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目的 探讨儿童型重症肌无力 (MG)的临床特点。方法 收集 1999年 9月至 2 0 0 2年 2月上海华山医院 4 4例儿童型MG患者的临床资料并进行回顾性分析。结果 3～ 5岁起病者为 4 3 2 % ,男女患病率之比为 1 2∶1;95 5 %起病时表现为眼肌型 ,其中仅 9 5 %进展为全身型 ;发病前有上呼吸道感染者占 18 2 % ;有 31 8%在发病后出汗增多 ;2 9 5 %的患者乙酰胆碱受体 (AchR)抗体阳性 ,31 8%的患者突触前膜受体 (PsmR)抗体阳性 ,5 0 %的患者神经节苷脂 1(GM1)IgM抗体阳性。结论 我国儿童型MG在患病率、性别、发病年龄、病情进展、实验室检查和治疗各方面有其自身特点。
Objective To investigate the clinical features of childhood myasthenia gravis (MG). Methods The clinical data of 44 cases of children with MG in Shanghai Huashan Hospital from September 1999 to February 2002 were collected and analyzed retrospectively. Results The incidence rate of 3 ~ 5 years old patients was 42.2%, the prevalence rate of male and female was 1 2:1. 95 95% patients showed ocular muscle type at onset, only 95% of them progressed to systemic type. There were 18 2% with upper respiratory tract infection, 31 8% with increased perspiration after onset, 25 25% with AchR positive, 31 8% with PsmR, Antibody positive, GMO IgM antibody is positive in 50% of patients. Conclusion Our children’s MG has its own characteristics in prevalence, gender, age of onset, disease progression, laboratory examination and treatment.