目的分析基底动脉尖综合征的临床特点。方法对15例TOBS患者的病史、症状、体征及其诊疗效果进行总结分析。结果15例TOBS患者中,高血压病史占第1位,其他依次为心脏病史、脑卒中史、糖尿病史,血流变学改变也是其原因之一。临床表现以眩晕、意识障碍、眼球运动异常、瞳孔异常、共济失调为主,大多数病情呈进展性,预后不良,死亡率高。头颅MRI为首选检查。治疗上要全面兼顾,既要重视溶栓治疗,又要全身治疗及并发症的防治。结论基底动脉尖综合征主要病因是脑梗死和脑栓塞,临床具有起病急、进展快、死亡率高的特点,及时诊断,合理治疗是关键。 Objective To analyze the clinical features of basilar artery syndrome. Methods The history, symptoms and signs of 15 patients with TOBS were analyzed. Results Among the 15 TOBS patients, the history of hypertension was the first one, followed by the history of heart disease, the history of stroke, the history of diabetes and the change of hemorheology. Clinical manifestations to dizziness, disturbance of consciousness, eye movement abnormalities, pupillary abnormalities, ataxia-based, most of the progress was progressive, poor prognosis, high mortality. Head MRI is the preferred examination. To take full account of the treatment, we must attach importance to thrombolytic therapy, but also systemic treatment and prevention and treatment of complications. Conclusions The main causes of basilar apical syndrome are cerebral infarction and cerebral embolism. The clinical features are acute onset, rapid progression and high mortality. It is crucial to timely diagnose and treat with reasonable treatment.