论文部分内容阅读
为了解接触多环芳烃职业人群遗传毒理学效应的改变，用外周血淋巴细胞培养的方法。检测了２３名沥青工、１９名焦炉工和１２名对照者的外周血淋巴细胞姐妹染色体互换（ＳＣＥ）。结果提示沥青工、焦炉工ＳＣＥ（１１．３１）明显高于对照（６．３７），差异有高度显著性（Ｐ＜０．００１）；按工种分层分析显示，沥青工ＳＣＥ（１０．２７）、焦炉工ＳＣＥ（１２．５８）也分别明显高于对照（Ｐ＜０．０１）；沥青工、焦炉工中，吸烟者ＳＣＥ（１１．７４）与不吸烟者ＳＣＥ（１０．９７）间差异无显著性（Ｐ＞０．０５）。此结果提示煤焦沥青和焦炉逸散物具有明显的遗传毒理学效应，对沥青工和焦炉工染色体可造成一定的损伤
To understand the genotoxic effects of PAH occupational populations, peripheral blood lymphocyte cultures were used. Peripheral blood lymphocyte Sisters Chromosome Interchange (SCE) was examined in 23 asphaltenes, 19 coke oven workers and 12 controls. The results showed that the SCE (11.31) of asphalt and coke oven workers was significantly higher than that of the control (6.37), the difference was highly significant (P <0.001). 27) and SCE (12.58) of coke oven workers were also significantly higher than those of the control (P <0.01). Among asphalt workers and coke oven workers, SCE (11.74) and non-smoker (SCE) 97) was no significant difference (P> 0.05). The results suggest that coal tar pitch and coke oven discharge have a significant genotoxic effect, astringent and coke oven workers chromosome can cause some damage