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α-Naphthylisothiocyanate(异硫氰酸萘酯,ANLT)可引起胆汁瘀滞而造成肝损害。以前曾对古典治疗肝病的67种生药的甲醇提取物,对大鼠CCl_4肝损害进行了研究。现就ANIT肝损害的保护作用报告如下。动物 wistar系雄性大白鼠,7周令,200g左右。提取物取67种生药粉末50g,用甲醇300ml提取2h,共3次。合并提取液,减压浓缩蒸去溶媒。用精制水溶解使pH7～8。于ANIT给药前30min,空腹投与1000mg/kg。
Alpha-Naphthylisothiocyanate (ANLT) can cause bile stasis and liver damage. The liver damage of rat CCl_4 was studied by methanol extracts of 67 crude drugs that were classically used to treat liver diseases. The current report on the protective effects of AIT liver damage is as follows. Animals wistar male rats, 7 weeks, about 200g. The extract was prepared by taking 50 g of 67 kinds of crude drug powder and extracting it with 300 ml of methanol for 2 hours for 3 times. The extracts were combined and concentrated under reduced pressure to remove the solvent. It was dissolved with purified water to a pH of 7-8. At 30 minutes before ANIT administration, 1000 mg/kg was administered on an empty stomach.